What is CFF test?

Critical flicker frequency (CFF) is a test of retinal gliopathy (that occurs in patients with HE) that can be performed using a portable machine. 25. During this test, the patient is asked to indicate the maximum frequency at which they can still perceive the light as flickering while changing the frequency over time.

What kind of drug is ivacaftor?

Ivacaftor is in a class of medications called cystic fibrosis transmembrane conductance regulator (CFTR) potentiators. It works by improving the function of a protein in the body to decrease the build-up of thick mucus in the lungs and improving other symptoms of cystic fibrosis.

What is the delta F508 mutation?

The most common mutation in the gene associated with cystic fibrosis (CF) causes deletion of phenylalanine at residue 508 (delta F508) of the gene product called CFTR. This mutation results in the synthesis of a variant CFTR protein that is defective in its ability to traffic to the plasma membrane.

What is ivacaftor used to treat?

Ivacaftor is a new therapeutic agent that acts at the cystic fibrosis transmembrane conductance regulator (CFTR) channel to alter activity. It is approved for use in patients 6 years and older with cystic fibrosis who have at least 1 G551D mutation in the CFTR gene.

What is the critical flicker fusion frequency?

Critical flicker fusion frequency (CFF or CFFF) is defined as the frequency at which flickering light can be perceived as continuous and it is used to assess the processing of temporal vision.

What is flicker fusion apparatus?

From Wikipedia, the free encyclopedia. The flicker fusion threshold, Critical Flicker Frequency (CFF) or flicker fusion rate, is a concept in the psychophysics of vision. It is defined as the frequency at which an intermittent light stimulus appears to be completely steady to the average human observer.

Who can take ivacaftor?

The U.S. Food and Drug Administration (FDA) today approved ivacaftor (Kalydeco®) for people ages 2 and older who have at least one of 23 residual function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.

Can cystic fibrosis shorten your life?

Cystic fibrosis (CF) is a progressive, genetic disease that affects roughly one in 5,000 people born in the United States. 1 It primarily affects the lungs and digestive system. People with CF experience chronic lung infections and inflammation, which cause progressive damage to their lungs and shorten their lifespan.

What is the frequency of human eye?

Some experts will tell you that the human eye can see between 30 and 60 frames per second. Some maintain that it’s not really possible for the human eye to perceive more than 60 frames per second.

What frequency a human eye can no longer detect blinking?

When a light is flickering at a frequency greater than 50 or so Hertz, most people can no longer distinguish between the individual flickers.