What is droperidol mechanism of action?

The exact mechanism of action is unknown, however, droperidol causes a CNS depression at subcortical levels of the brain, midbrain, and brainstem reticular formation. It may antagonize the actions of glutamic acid within the extrapyramidal system.

What is the action of metoclopramide?

Metoclopramide works by blocking a natural substance (dopamine). It speeds up stomach emptying and movement of the upper intestines. This drug is not recommended for use in children due to an increased risk of serious side effects (such as muscle spasms/uncontrolled muscle movements).

What type of drug is droperidol?

Droperidol is a sedative, tranquilizer, and anti-nausea medicine. Droperidol is used to reduce nausea and vomiting caused by surgery or other medical procedures.

What is the difference between haloperidol and droperidol?

Droperidol has a more predictable and rapid onset of 3–10 minutes, and both have peak pharmacologic effects that occur within 30–40 minutes of an intramuscular injection. Both drugs are metabolized principally by the liver. The serum half-life for haloperidol is 12–24 hours.

Why was droperidol taken off the market?

In 2001, however, the US Food and Drug Administration (FDA) placed a black box warning on droperidol over concerns about potential cardiac adverse effects. The fallout was swift, and droperidol vanished almost overnight from hospital formularies, leaving hospital staff to scramble for alternatives.

Why does droperidol still carry a black box warning?

The side effects of droperidol include extrapyramidal effects (akathisia and dystonia), sedation, hypotension (through mild alpha adrenergic blockade and peripheral vascular dilation), and QTc prolongation. In 2001, the FDA issued a black box warning due to concerns about QT prolongation and torsade de pointes.

Is INAPSINE a controlled substance?

Innovar is a DEA Schedule II controlled substance. Substances in the DEA Schedule II have a high potential for abuse which may lead to severe psychological or physical dependence.

What type of drug is metoclopramide?

Reglan belongs to a class of drugs called Antiemetic Agents; Prokinetic Agents.

Can droperidol cause anxiety?

The most common behavioral adverse effects of INAPSINE (droperidol) include dysphoria, postoperative drowsiness, restlessness, hyperactivity and anxiety, which can either be the result of an inadequate dosage (lack of adequate treatment effect) or of an adverse drug reaction (part of the symptom complex of akathisia).