What is focal acantholytic dyskeratosis?

Focal acantholytic dyskeratosis (FAD) is a distinctive histologic pattern characterized by suprabasilar clefts surrounding dermal papillae (villi), acantholytic and dyskeratotic cells at all levels of the epidermis, hyperkeratosis, and parakeratosis.

Is Focal acantholytic dyskeratosis benign?

Acantholytic dyskeratotic acanthoma (ADA) is a rare benign condition characterized by circumscribed epidermal proliferation displaying both acantholysis and dyskeratosis.

What causes acantholytic dyskeratosis?

Drug-induced transient acantholytic dermatosis may be due to the drug or its metabolites being excreted in the sweat with toxic effects on the adjacent epidermis causing acantholysis and dyskeratosis. BRAF-induced Grover disease may result from keratinocyte proliferation via activation of the MAP-kinase pathway.

What is acantholytic?

Abstract. Acantholysis means loss of coherence between epidermal cells due to the breakdown of intercellular bridges. It is an important pathogenetic mechanism underlying various bullous disorders, particularly the pemphigus group, as well as many non-blistering disorders.

What is acantholytic squamous cell carcinoma?

Adenoid (acantholytic) squamous cell carcinoma (ASCC) is a histological variant of squamous cell carcinoma which occurs mainly in the sun-exposed areas of the head and neck region. It is commonly seen among males which mainly occurs in the sixth and seventh decade of life with lip being predominately affected.

Is Grover’s disease painful?

Grover’s disease is a skin condition that causes the appearance of small, red spots. These spots usually develop on the chest or back, but may also form on other parts of the body. This condition frequently leads to intense itching, although it may cause no symptoms. Most cases last six to twelve months.

What is Acantholytic keratosis?

Acantholytic actinic keratosis has been regarded as a precursor of acantholytic squamous cell carcinoma (SCC), a reportedly aggressive high-risk form of SCC.

What is the cause of Grover’s disease?

The exact cause of Grover’s disease is not known. It may be related to fragility of old sun-damaged skin. Some doctors feel that this skin disorder may be related to heat and sweating.

What is Grovers?

General Discussion. Grover’s disease is a rare, transient skin disorder that consists of small, firm, raised red lesions, most often on the skin of the chest and back. Diagnosis of this disorder becomes apparent under microscopic examination when the loss of the “cement” that holds the skin cells together is observed.

Although the term ‘focal acantholytic dyskeratosis’ is often used both for clinically inapparent incidental foci and for clinically apparent solitary lesions with the histological pattern of acantholytic dyskeratosis,990 some authors restrict its use to its incidental finding in histological sections.

What is acantholytic acanthoma without dyskeratosis?

Acantholytic acanthoma was originally described as a solitary lesion displaying histologic features of acantholysis without dyskeratosis. Solitary, non-genital lesions displaying confluent acantholysis and dyskeratosis have not been well described in the literature, clinically or histologically. We …

What is papular acantholytic dyskeratoma?

The term ‘papular acantholytic dyskeratoma’ has been applied to the clinically apparent solitary lesions, 994 and ‘papular acantholytic dyskeratosis’ to the exceedingly rare cases in which multiple lesions have developed on the vulva, 995–1001 perianal area, 1002–1004 or penis 1005 (see below).

What is acantholytic acanthoma?

Acantholytic acanthoma was originally described as a solitary lesion displaying histologic features of acantholysis without dyskeratosis. Solitary, non-genital lesions displaying confluent acantholysis and dyskeratosis have not been well described in the literature, clinically or histologically.