What is Jod-Basedow?

The Jod-Basedow effect (also Jod-Basedow syndrome and Jod-Basedow phenomenon) is hyperthyroidism following administration of iodine or iodide, either as a dietary supplement, iodinated contrast medical imaging, or as a medication (mainly Amiodarone).

What is meant by Wolff-Chaikoff effect?

The Wolff-Chaikoff effect is an effective means of rejecting the large quantities of iodide and therefore preventing the thyroid from synthesizing large quantities of thyroid hormones.

How long does Jod Basedow phenomenon last?

This phenomenon is known by the name of the Wolff-Chaikoff effect and is thought to be caused by a temporary downregulation of the sodium iodide transporter in the thyroid. Most patients can return to a euthyroid state within 24 to 48 hours.

Why does Wolff-Chaikoff effect occur?

The Wolff–Chaikoff effect is a presumed reduction in thyroid hormone levels caused by ingestion of a large amount of iodine.

Does Graves disease cause clubbing?

Acropachy refers to a dermopathy associated with Graves’ disease. It is characterized by soft-tissue swelling of the hands and clubbing of the fingers. Radiographic imaging of affected extremities typically demonstrates periostitis, most commonly the metacarpal bones.

How does potassium iodide cause hypothyroidism?

The saturated potassium iodide solution (SSKI) as treatment for sporotrichosis may cause hypothyroidism by suppressing the synthesis of thyroid hormones (tT3 and tT4 ) and the iodine excess could lead to thyrotoxicosis.

Is methimazole an immunosuppressant?

The immunosuppressive effect of methimazole on cell-mediated immunity is mediated by its capacity to inhibit peroxidase and to scavenge free oxygen radicals. Clin Endocrinol (Oxf).

Can methimazole Cure Graves disease?

Antithyroid drugs such as propylthiouracil (Propacil) and methimazole (Tapazole), which interfere with thyroid hormone production, can be used to treat Graves’ disease.

Does hyperthyroidism cause clubbing?

Thyroid acropachy is a rare complication of autoimmune thyroid disease with characteristic imaging findings. Clinically, it presents as nail clubbing, swelling of digits and toes, almost always in association with thyroid ophthalmopathy and dermopathy.

What causes finger clubbing in hyperthyroidism?

Thyroid acropachy presents with digital clubbing, swelling, and periosteal reaction of the phalanges. It is almost always associated with ophthalmopathy, thyroid dermopathy, or both and is an indicator for the severity of the underlying autoimmune process.