What is the function of IL-15?

Interleukin-15 (IL-15) is a pleiotropic cytokine with a broad range of biological functions in many diverse cell types. It plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems.

What is NKG2D receptor?

NKG2D is an activating receptor (transmembrane protein) belonging to the NKG2 family of C-type lectin-like receptors. NKG2D is encoded by KLRK1 (killer cell lectin like receptor K1) gene which is located in the NK-gene complex (NKC) situated on chromosome 6 in mice and chromosome 12 in humans.

What is NKG2D ligand?

Human and mouse NKG2D ligands are structural homologs of MHC class I molecules. All ligands consist of two ectodomains that are distantly related to the α1 and α2 domains of the MHC class I protein. Unlike other ligands, MICA and MICB contain an α3-like domain in addition to the α1 and α2 domains (36).

What cells express NKG2D?

NKG2D, encoded by Klrk1, is an activating cell surface receptor that is predominantly expressed on cytotoxic immune cells. NKG2D is abundantly present on all NK cells, NKT cells, and subsets of γδ T cells. While naïve human CD8+ T cells express NKG2D, in mice they upregulate its expression only after activation (1).

Is IL-15 anti inflammatory?

How is IL-15 produced?

Interleukin 15 (IL-15) is a cytokine that is produced by monocytes. It is an activator of T lymphocytes and a stimulator of natural killer cell proliferation and activation. Furthermore, IL-15 induces cytokine production by monocytes and polymorphonuclear cells and stimulates the antimicrobial activity of phagocytes.

What does NKG2D bind to?

The activating receptor NKG2D can directly bind to a diverse family of ligand molecules expressed on the surface of tumor cells. In NK cells, NKG2D interacts with either DAP10 (both human and mouse) or DAP12 (mouse only) and induces cytotoxicity and IFN-γ production.

What is MIC in immunology?

Abstract. Major histocompatibility complex (MHC) class I chain related (MIC) molecules show homology with classical human leukocyte antigen (HLA) molecules, but they do not combine with beta2 microglobulin, do not bind peptide and are not expressed on normal circulating lymphocytes.

Is NKG2D on T cells?

NKG2D is present on all murine and human NK cells. It is constitutively expressed on human CD8+ T cells, whereas its expression on CD8+ T cells occurs after activation in mice.

Is IL-15 pro or anti inflammatory?