What is the meaning of JCV?

JC virus: A virus that commonly causes infections of no consequence in children with a normal immune system, but which is responsible for an infection of the brain and spinal cord called progressive multifocal leukoencephalopathy (PML) in people with AIDS and other forms of immune system impairment. Abbreviated JVC.

What is JCV status?

When someone says that they’re “JCV-positive,” or “JCV+,” they mean that they’ve had a blood test that was positive for anti-JCV antibodies. Most people with MS are likely to have been tested for the JC virus early in their treatment.

What causes JCV?

What was the primary source from which the infection spread? PML is due to the reactivation of JC virus, a human polyomavirus, which causes a lytic infection of the oligodendrocytes in the brain. The asymptomatic JC virus primary infection occurs most likely as a result of urine-oral transmission in childhood.

Is JC virus curable?

There is no cure once the JC virus enters the brain and causes PML, but if the infection is caught soon enough there are treatments that may reduce the risk of longterm complications.

How do you prevent JC virus?

There is no effective antiviral therapy for preventing or treating JCV infections or PML. The main approach to treatment is to preserve immune function and reverse HIV-associated immunosuppression with effective ART.

Can you test for JC virus?

Tests can detect if you carry the JC virus. Your doctor might look at a sample of your tissue under a microscope or check your blood for signs that your body is fighting the infection. This is important to know in case you have a weakened immune system or if you take drugs that suppress your immune system.

What type of virus is JC virus?

JC virus (JCV) is a human neurotropic polyomavirus that is the etiologic agent of progressive multifocal leukoencephalopathy (PML). PML is a rare, fatal, demyelinating disease of the central nervous system (CNS) which almost always occurs in an immunocompromised patient.

Can you get JC virus as an adult?

At least half of all adults have the JC virus in their system. In most people, it is dormant and does not directly cause health problems. However, it can trigger a serious condition called progressive multifocal leukoencephalopathy (PML). This can lead to severe complications.

How is the stratify JCV ® test performed?

In the Focus Diagnostics’ STRATIFY JCV. ®. DxSelect™ test, JC virus-like particles (VLP) are pre-coated onto 96-well microtiter plates. Diluted serum or plasma specimens and controls are incubated in the wells to allow JCV-specific antibodies present in the specimens to react with the JC VLP antigen.

What does JCV stand for?

Stratify™ JCV Antibody (with Index) with Reflex to Inhibition Assay – The JC Virus (JCV) is associated with progressive multifocal leukoencephalopathy (PML). Detection of antibodies to JCV in serum or plasma is a reliable indicator of exposure to JCV. The analytical performance characteristics were determined for multiple sclerosis patients.

What is unilabsweb stratify JCV?

Welcome to UnilabsWEB Stratify JCV. This website is a closed site, and is only intended for neurologists registered for the Stratify JCV Test and CSF JCV DNA tests. The purpose of this site is to provide relevant information, as well as to allow the user to order sampling material, book pick-up of samples and view results.

What does stratify stand for?

JC-Virus (JCV) Antibody Program (STRATIFY-1) This study requires serum, plasma and urine collection at enrollment and every 6 months thereafter for up two years.