What is the pKa of diphenhydramine?
8.87
3D Structure for HMDB0001927 (Diphenhydramine)
| Property | Value | Source |
|---|---|---|
| logP | 3.44 g/L | ALOGPS |
| logP | 3.65 g/L | ChemAxon |
| logS | -3.5 g/L | ALOGPS |
| pKa (Strongest Basic) | 8.87 | ChemAxon |
Is diphenhydramine HCl acidic or basic?
acidic
Diphenhydramine hydrochloride has the appearance of a white crystalline powder. It is odorless and has a bitter, numbing taste. It is soluble in water and aqueous solutions are acidic.
What is the HCl in diphenhydramine?
Description. Diphenhydramine Hydrochloride is the hydrochloride salt form of diphenhydramine, an ethanolamine and first-generation histamine antagonist with anti-allergic activity.
Is diphenhydramine HCl the same as diphenhydramine?
The difference between diphenhydramine hydrochloride and diphenhydramine citrate is that the salt used to bind the diphenhydramine, is different. For diphenhydramine hydrochloride the salt is hydrochloride and for diphenhydramine citrate the salt is citrate.
Is diphenhydramine first generation antihistamines?
First-generation antihistamines are primarily over-the-counter OTC) and are included in many combination products for cough, colds, and allergies. These include brompheniramine, chlorpheniramine (Chlor-Trimeton), and diphenhydramine (Benadryl).
Can I give my dog diphenhydramine HCL?
Benadryl, or diphenhydramine, is an antihistamine that helps relieve the symptoms of allergies in both humans and animals. It can also be used to relieve the symptoms of motion sickness if a dog needs to be transported long distances. For most dogs, the appropriate dosage of Benadryl is perfectly safe.
Is diphenhydramine oil soluble?
Diphenhydramine hydrochloride, 2-(diphenylmethoxy)- N,N-dimethylethanamine hydrochloride (Benadryl), is an oily, lipid-soluble free base available as the bitter-tasting hydrochloride salt, which is a stable, white crystalline powder soluble in water (1:1), alcohol (1:2) and chloroform (1:2).
Does diphenhydramine HCl make you sleepy?
Diphenhydramine is an antihistamine medicine that relieves the symptoms of allergies. It’s known as a drowsy (sedating) antihistamine and is more likely to make you feel sleepy than other antihistamines.
What is diphenhydramine HCI 25mg used for?
Diphenhydramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, itching, watery eyes, itchy eyes/nose/throat, cough, runny nose, and sneezing. It is also used to prevent and treat nausea, vomiting and dizziness caused by motion sickness.
What is better cetirizine or diphenhydramine?
CONCLUSIONS: Cetirizine has similar efficacy as compared with diphenhydramine in treating acute food allergic reactions. With the added benefits of longer duration of action and less sedation, cetirizine is a good treatment option for acute food allergic reactions.