WHO histological classification of gastric Tumours?
The 2010 WHO classification recognizes four major histologic patterns of gastric cancers: tubular, papillary, mucinous and poorly cohesive (including signet ring cell carcinoma), plus uncommon histologic variants (24).
What is gastric cardia tumor?
Pragmatically, the term cardia cancer is applied to adenocarcinomas involving primarily the proximal stomach near to or including the gastro-oesophageal junction. Histologically, these cancers are usually (80%) of the intestinal type and presumed to have arisen from metaplastic intestinal metaplasia.
What is the function of the cardia in the stomach?
The part of the stomach that is closest to the esophagus. Food and liquids pass through the cardia to enter the stomach from the esophagus. A valve near the cardia helps keep stomach contents from backing up into the esophagus.
What is gastric cardia mucosa?
The gastric cardia is generally defined as the area of mucosa located distal to the anatomic gastroesophageal junction (GEJ) and proximal to the oxyntic mucosa of the gastric body. It is an area of the stomach that raises many controversies about its native glandular components.
What are the histologic patterns of gastric cancer?
The 2010 WHO classification recognizes four major histologic patterns of gastric cancers: tubular, papillary, mucinous and poorly cohesive (including signet ring cell carcinoma), plus uncommon histologic variants ( 24 ).
What are the histologic characteristics of tubular adenocarcinoma of the stomach?
Tubular adenocarcinoma is the most common histologic type of early gastric carcinoma (Figure 1). It tends to form polypoid or fungating masses grossly, and histologically demonstrates irregularly distended, fused or branching tubules of various sizes, often with intraluminal mucus, nuclear and inflammatory debris. Open in a separate window Figure 1
Are esophageal and gastric cancers of the cardia separate tumors?
Carcinomas of the cardia are regarded to share features of both, esophageal and gastric cancers. Controversy exists concerning their appropriate classification and whether these tumors comprise–in respect to tumor biology, pathophysiology as well as clinical features–an entirely separate entity.
Is cardiac cancer really stomach in origin?
When the tumor stage is studied and compared with cumulative survival, the findings support that it is more appropriately to group and stage cardiac cancers as stomach in origin (10).