Why are C57BL 6 mice used?

C57BL/6 mice is an inbred mouse strain originally developed for the study of antitumor activity and immunology, and is increasingly being used as an basic background strain. It is known that cell-mediated immunity and NK cell activity are of relatively high importance in determining immunological characteristics.

Are C57BL 6 mice genetically modified?

Our C57BL/6 mouse colonies are genetically identical within each strain, making them free of genetic differences that could impact research results.

What is the difference between BALB C and C57BL 6 mice?

BALB/c mice tend to produce a stronger humoral response than C57BL/6 mice. These strains have different gene sequences at the H2 site of the major histocompatibility (MHC)class I gene locus – BALB/c mice is H2d, while C57BL/6 is H2b. The difference in gene sequence of these two strains falls on the H2 locus.

Why are C57 mice used?

C57BL/6J mice are used in a wide variety of research areas including cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and sensorineural research. C57BL/6J mice are also commonly used in the production of transgenic mice.

Is C57BL 6 mice wild type?

C57BL/6 mice are widely used in biomedical research for the background of genetically engineered mice (GEM) and wild-type controls with the belief that the genetic background of GEM and control mice differ significantly by only one or more altered gene.

What does C57BL stand for?

C57BL/6, often referred to as “C57 black 6”, “C57” or “black 6”, is a common inbred strain of laboratory mouse. It is the most widely used “genetic background” for genetically modified mice for use as models of human disease.

What species is C57BL 6 mice?

Do BALB c mice have an immune system?

Other studies revealed that in contrast to C57BL/6 mice, which show a Th1- and M1-dominant immune response, BALB/c mice show a more Th2- and M2-dominant immune response [17, 19].

Are BALB c mice wild type?

BALB/c wild-type mice were obtained from the Walter and Eliza Hall Institute for Medical Research and were maintained at the Peter MacCallum Cancer Centre.

What is the difference between C57BL 6 and C57BL 6J?

C57BL/6J is the parental substrain; “J” is the laboratory code for The Jackson Laboratory. Therefore, there is no source of “C57BL/6” mice; there is always a longer designation for each substrain indicating the institute or laboratory that maintains the different colonies.

Are C57BL 6 mice wild type?

Why are BALB c mice used in immunology?

BALB/cJ mice are frequently used for a variety of immunological studies, in part because they demonstrate TH2-biased immune responses. BALB/c mice are particularly well known for the production of plasmacytoma on injection with mineral oil, forming the basis for the production of monoclonal antibodies.